L-Carosine is a dipeptide found at millimolar concentration in brain, muscle and the lens of the eye. In model systems it is a potent antioxidant that scavenges oxygen free radicals and transition metal ions. It blocks protein-protein and protein-DNA cross-links induced by hypochlorite anions and toxic aldehydes such as acetaldehyde, formaldehyde, and malondialdehyde, the primary product of lipid peroxidation. It also inhibits nonenzymatic protein glycation induced by aldose and ketose reducing sugars and inhibits the formation of toxic advanced glycation end products (AGE). These activities make it of interest in studies of aging, atherosclerosis, Alzheimer′s disease, and the secondary effects of diabetes.
L-Carnosine is classified as a diapeptide, which is a combination of two amino acids, in this case alanine and histidine. It naturally occurs in high concentrations in skeletal muscle tissue, and therefore may support muscle vitality. L-Carnosine is also an antioxidant that stabilizes cellular membranes, protecting them from damage by free radicals. Because L-Carnosine is only found in vertebrates, it is especially important for persons who do not consume beef, pork or chicken.
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